416 Effectiveness and safety of rituximab in recalcitrant pemphigoid diseases
نویسندگان
چکیده
منابع مشابه
Effectiveness and Safety of Rituximab in Recalcitrant Pemphigoid Diseases
Introduction Rituximab (RTX) is a monoclonal antibody targeting CD20, a transmembrane protein expressed on B cells, causing B cell depletion. RTX has shown great efficacy in studies of pemphigus vulgaris, but data of pemphigoid diseases are limited. Objective To assess the effectiveness and safety of RTX in pemphigoid diseases. Methods The medical records of 28 patients with pemphigoid dise...
متن کاملA recalcitrant case of cicatricial pemphigoid.
A 57-year-old woman presented with a 1-year history of blisters and erosions on her oral mucosa with bilateral conjunctivitis and symblephara formation. A diagnosis of cicatricial pemphigoid was made based on the clinical features and immunohistological findings. A multidisciplinary team managed her with different topical and systemic immunosuppressive agents but she finally succumbed due to mu...
متن کاملeffectiveness of hedstroum files and rotary k3 instruments in removal of obturation materials during retreatment in curved canals
چکیده ندارد.
15 صفحه اولSafety of rituximab in children with auto-immune diseases
Results We identified 169 children treated for refractory AID: autoimmune cytopenia (s) (104 patients), systemic lupus erythematosus (SLE) (52 patients), miscellaneous (13 patients). The mean follow-up period was 6 to 36 months. Patients received 2 to 4 rituximab infusions (350–750 mg/m2) associated with immunosuppressive drugs in 49/ 52 SLE patients. Replacement intravenous immunoglobulins the...
متن کاملRituximab therapy improves recalcitrant Pemphigus vulgaris
Pemphigus is a severe life-threatening blistering disease associated with autoantibodies against cell adhesion proteins desmogleins 1 and 3. Patients with severe pemphigus commonly show high rates of relapse after conventional immunosuppressive therapy. The newly developed drug Rituximab showed impressing promises in the treatment of refractory pemphigus vulgaris (PV). In the present study the ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2018
ISSN: 0022-202X
DOI: 10.1016/j.jid.2018.03.423